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Paradigm Shift Intervention Monitoring
Has Abolished HA Glycosylation Site
This change, as well as the associated changes in the Iowa isolate, is widespread in the United States, signaling serious vaccine failures, CDC FluView claims of matches in 99.3% of H3N2 sequences not withstanding. H3N2 is rapidly spreading in the United States, leading to physician claims of vaccine failures. In addition to the presence of these changes in 2 of 2 recent sequences from England, these changes are also common in Japan and Taiwan raising additional concerns that these changes found in a sequence designated by the CDC as a low reactor, have spread throughout the northern hemisphere.
In addition to A/Victoria/361-like sequences with T128A, the second low reactor, A/Hawaii/29/2012, with L157S is also raising concerns. Today the CDC released sequences for A/Hawaii/22/2012 X-225A which is being tested as a new H3N2 vaccine target which has L157S.