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Paradigm Shift

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Paradigm Shift

The analysis of recombination will generate a paradigm shift in the way molecular evolution is viewed.  Influenza is an ideal system for studying molecular evolution. Viruses are generally thought to evolve via shifting and drifting.  Shifting occurs when viruses swap genes and drifting was thought to be due to a steady accumulation of mutations. 


However, rapidly evolving viruses simply recycle old mutations via recombination.  This method is much more efficient and follows specific rules.  These rules appear to be followed by all viruses, including influenza, HIV, SARS, WNV.  These rules allow vaccines to be prepared before viruses emerge.  These observations will produce a paradigm shift in the study of molecular evolution via recombination, which will provide solutions for unmet health needs

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