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Paradigm Shift Intervention Monitoring
Links US H3N2v China H5N1 Swiss H1N1v
The H1N1v case (55M), A/Wisconsin/28/2011, had an occupational swine exposure, but many of the newly acquired polymorphisms of the internal genes are also present in the US H3N2v and H1N2v cases.
However, newly acquired internal gene polymorphisms are also found in H5N1 cases in China (A/Guangdong-Shenzhen/1/2011, A/Hubei/1/2010, A/Guangxi/1/2009) and Cambodia, as well as three H1N1v cases in Switzerland (A/Switzerland/9356/2009, A/Switzerland/5165/2010, A/Switzerland/4607377/2011) –see list here.
The acquisitions are via recombination and linked to wild bird sequences which raises concerns of rapid evolution in these novel influenza genomes.