Recombinomics | Elegant Evolution

Home Founder What's New In The News Consulting

H1N1 Consulting

Paradigm Shift

Viral Evolution

Intervention Monitoring

Vaccine Screening

Vaccine Development

Expression Profiling

Drug Discovery

Custom Therapies


Audio:Nov 24 Dec2 Dec17 Dec30 RSS Feed twitter News Now                         
Live feed of underlying pandemic map data here

Fatal H1N1 Cluster in Romania Raises Concerns
Recombinomics Commentary 19:42
January 12, 2010

This is a woman of 42 years of Caracal, mother of a young friend of 21 years died a few days ago, confirmed also A/H1N1 virus. The two did not become ill from one another but had a common source from which they contracted the virus, "said Madan Marinela

The above translation describes two fatal H1N1 infections in Caracal, Romania which were said to have come from a common source.  Although fatalities in eastern Europe have been rising, the case fatality rate has been well below 0.1%. Therefore the deaths of two patients from a common source would be cause for concern.

Recently released sequences from the region have had receptor binding domain change at position 225.  Two such changes, D225G and D225N have been linked to a case fatality rate of 100% in many of the countries in the region.

Since detection of these two polymorphisms is low, the overall H1N1 is also low, but there are concerns that an increase in frequency in such sequences would lead to clear transmission and a dramatic jump in CFR.  The first indication of such changes would be clusters of cases such was the two described above.

More information on these two cases and the common source would be useful.

Media Links

Recombinomics Presentations

Recombinomics Publications

Recombinomics Paper at Nature Precedings

Home | Founder | What's New | In The News | Contact Us

© 2010 Recombinomics.  All rights reserved.