Recombinomics | Elegant Evolution

Home Founder What's New In The News Consulting

H1N1 Consulting

Paradigm Shift

Viral Evolution

Intervention Monitoring

Vaccine Screening

Vaccine Development

Expression Profiling

Drug Discovery

Custom Therapies


Audio:Jan4 Jan20 Feb17 Mar17 RSS Feed twitter News Now                         


Novel H1N1 Vaccine Breakthrough Raises Pandemic Concerns

Recombinomics Commentary 22:50
April 8, 2011

The recent H1N1 outbreaks in Mexico and Venezuela have raised concerns that a novel and virulent H1N1 is rapidly spreading throughout the region.  This concern has generated serious vaccination campaigns in both countries.  However, recently released sequence by the US Air Force included five isolates with the novel sub-clade.  Included in the five were two isolates from vaccinated patients (44M and 37M) in Arizona, A/Arizona/AF21768/2011, and New Jersey, A/New Jersey/AF21791/2011, respectively.

The novel sub-clade contains four non-synonymous changes, N34D, S165N, A189T, and V275I, which are present in all of the recent isolates (mid 2010 through 2011).  The New Jersey HA sequence has only the four changes noted above, indicating all novel sub-clade members have all changes required to generate a vaccine breakthrough (failure).  This failure is likely linked to A189T, which is adjacent to receptor binding position 190, and S165N, which creates a new glycosylation site.  Thus, it is ikely that the vaccination efforts in Chihuahua, Mexico and Venezuela will have limited success.

Moreover, anecdotal reports indicates that the novel sub-clade in Mexico is also causing outbreaks in Venezuela as well as multiple countries in Central and South America, signaling rapid spread of this H1N1 sub-clade in a pattern that mirrors the spread of H1N1 in 2009.

In addition, anecdotal reports indicate D225N is over-represented in these cases, raising concerns of an increased frequency of severe and fatal cases, as seen in Chihuahua, Mexico.

Release of 2011 sequences by the CDC, as well as other countries reporting an increase of H1N1 activity in the past several weeks is overdue.

Media link

Recombinomics Presentations

Recombinomics Publications

Recombinomics Paper at Nature Precedings

Home | Founder | What's New | In The News | Contact Us

© 2011 Recombinomics.  All rights reserved.