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Utah West Virginia H3N2v Match Signals Human Transmission
Recombinomics Commentary 14:15
April 13, 2012

The CDC has released a full set of sequences (at GISAID) from the Utah (F, <5) H3N2v case, A/Utah/10/2012, which is closely related to the 2011 H3N2v cases, with an N2 that is closely related to A/West Virginia/06/2011.

The N2 from West Virginia is from a lineage found in swine H3N2, in contrast to the first 10 H3N2 human sequences, which have an N2 related to swine H1N2 (although both lineages trace back to N2 from 2003 seasonal H3N2).

These sequences indicated that the 2012 H3n2 isolates is closely related to the 2011 sequences from West Virginia, which were linked to a cluster of 23 contacts with the Mineral County day care center.  This constellation has never been reported in swine.

These sequences strongly suggest that H3N2v continues to transmit in humans and more cases of H3N2v will be reported in 2012 than the 12 cases reported in 2011.

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