|Home||Founder||What's New||In The News||Consulting|
Paradigm Shift Intervention Monitoring
The Air Force presentation at
the 2011/2012 vaccine advisory committee meeting is available
at the FDA website. Slide 11 has a phylogenetic tree with recent
isolates, including 4 HA sequences from Ecuador. All four match
sub-clade, including the rare polymorphisms K149N,
which is in the isolates from Mexico as well as eight
isolates from the United States. Three of the sequences
A/Ecuador/IEC00032/2010) were collected in December, 2010, while the
fourth sequence, A/Ecuador/IEC00043/2011, was collected in January,
2011 matching the date for the WHO
2011 pandemic warning of H1N1 in Ecuador in January, 2011.
Moreover, one of the four sequences, A/Ecuador/IEC00012/2010, also has D225N, confirming the “anecdotal” reports indicating the Chihuahua sub-clade with D225N in severe and fatal cases was circulating in South America (as well as Mexico and the United States). The presence of D225N in one of the four sequence once again highlights the high frequency of detection in severe and fatal cases, which is a considerable concern because it is detected in the upper respiratory tract and is likely present at a higher frequency in samples collected from the lower respiratory tract.
These data confirm the focus of the WHO pandemic alert which is the growing presence of the novel Chihuahua sub-clade with D225N.
Release of the additional sequences from Mexico with D225N, as well as sequences from severe and fatal cases in countries cited in the WHO pandemic alert would be useful.