Recombinomics | Elegant Evolution

Home Founder What's New In The News Consulting

H1N1 Consulting

Paradigm Shift

Viral Evolution

Intervention Monitoring

Vaccine Screening

Vaccine Development

Expression Profiling

Drug Discovery

Custom Therapies


Audio:Apr23 May2 May12 MAP RSS Feed twitter News Now                         


Evolving Novel MERS Jeddah Sub-Clade Confirmed In Florida
Recombinomics Commentary 23:30
May 14, 2014

The recently described novel Jeddah MERS sub-clade has raised concerns.  It was found in 6/6 sequences from Jeddah and Mecca (from 4 hospitals) and matched 25 spike sequences from 25 more cases in Jeddah.  Moreover, recent exports (7 to 6 countries) have also been from Jeddah, including the case in Orlando, Florida.

The CDC recently released the Spike and N gene sequences,
Greece-Saudi Arabia_2014, from the case in Greece, which confirmed the presence of an evolving sub-clade, which had the expected markers as well as additional changes in the S gene (R511P) and the ORF8b gene (T31I) signaling rapid evolution.

The CDC has released the full sequences from the case (44M) in Orlando, Florida, Florida/USA-2_Saudi Arabia_2014, and are to be commended for the rapid release of these important sequences. 

Like the sequences from Greece, Orlando is also an evolving Jeddah sub-clade.  It also had the expected markers in the Spike and ORF8b genes, as well as a novel change in the Spike gene, S684F.

The confirmation of the same Jeddah sub-clade in Greece and Orlando, Florida as found in Jeddah and Mecca raises serious pandemic concerns.

Media Link

Recombinomics Presentations

Recombinomics Publications

Recombinomics Paper at Nature Precedings

Home | Founder | What's New | In The News | Contact Us

© 2014 Recombinomics.  All rights reserved.