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Paradigm Shift Intervention Monitoring
Tamiflu Resistance Spreads to California and Illinois
In addition, two recent isolates from California (A/California/21/2012) and Illinois (A/Illinois/1/2012) also had H274Y and were also closely related to the sequences from Texas and Mexico, signaling a broader clonal expansion.
The CDC’s week 19 Fluview notes that most of these isolates from cases not receiving anti0viral treatment, as well as two cases where family members were receiving treatment. These observations support transmission of H274Y.
Moreover, two of the recently released sequences (A/Texas/34/2012 and A/California/21/2012) also had D225G raising concerns of increases in severe Tamiflu resistant cases.