Recombinomics | Elegant Evolution

Home Founder What's New In The News Consulting

H1N1 Consulting

Paradigm Shift

Viral Evolution

Intervention Monitoring

Vaccine Screening

Vaccine Development

Expression Profiling

Drug Discovery

Custom Therapies


Audio:Apr29 May2 May16 MAP RSS Feed twitter News Now                         


H7 G228S Raises H7N9 Pandemic Concerns
Recombinomics Commentary 23:45
May 22, 2013

Both isolates had potentially functional amino acid sites related to mammal- or human-adapting substitution T189A, Q226L, and G228S (H3 numbering) in the receptor-binding site of hemagglutinin.

The above comments from a New England Journal of Medicine paper, Live-Animal Markets and Influenza A (H7N9) Virus Infection, cite the second key receptor binding domain change in H7, G228S in A/Nanjing/1/2013 and A/environment/Nanjing/2913/2013. 

The NEJM quote is INCORRECT.  The above links were activated by Genbank today and G228S is NOT present in either sequence.

The combination of Q226L and G228S was present in the 1957 H2N2 pandemic and well as the 1968 H3N2 pandemic, and both changes were introduced into two of the three H5N1 bird flu transmission experiments (the other experment used N224K and Q226L and the recently released sequence, A/Shanghai/patient1/2013, has N224I and Q226L).

The appearance of these changes in H7N9 may be facilitated by the H9N2 internal genes. 

However, the presence of Q226L and G228S in the above case (45F) raises serious pandemic concerns.

Media Link

Recombinomics Presentations

Recombinomics Publications

Recombinomics Paper at Nature Precedings

Home | Founder | What's New | In The News | Contact Us

© 2013 Recombinomics.  All rights reserved.