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Another Fatal H5N1 Bird Flu Cluster in Tangerang Indonesia

Recombinomics Commentary

June 2, 2006

the Department of the Health, on Friday (2/6), stated two citizens from Street Arya Putra, the District kedaung, Ciputat, Tangerang, Banten, positive died resulting from the bird flu virus.The bird flu patient was named Yohana died in the Fatmawati Hospital on last Thursday the night.Yohana was second casualties who still were having the family's relations with other casualties.Beforehand, the older brother Yohana, Toni, died on May 29 2006

The above translation describes another familial cluster in Tangerang on the outskirts of Jakarta.  No sample was collected for the index case, who died three days before his (10M), sister (7F), who was H5N1 positive.  The location is near the first reported familial cluster in July of 2005.  The sequence of H5N1 from the cluster has a novel cleavage site, which has been found in virtually all isolates from the West Java area, but the reported sequences from birds in the area have the wild type cleavage site raising questions about the origin of the infections.

The H5N1 in the Jakarta area is also distinct from the H5N1 linked to the large cluster in north Sumatra, which are amantadine resistant, as well as the second reported case in the Jakarta area, which has PB2 E627K.

Additional sequences from wild and domestic birds and other H5N1 hosts in the area would be useful.

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