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Altered Receptor Binding in  H5N1 Bird Flu in Indonesia?

Recombinomics Commentary

June 8, 2006

This difficulty was caused by two matters that is receptor relations and spesifisitas the receptor and the difference of the temperature between the person and the poultry also were different.

Therefore, I carried out the research in the month February-March 2006.

This research was helped by Tokyo University.

The aim of the research to know whether the circulating virus in the field, only had the shape of the virus from the poultry that is had spesifisitas the receptor alfa 2,3 or that had spesifisitas the receptor alfa 2,6 that is the virus that could infect direct to the mammal (the pig and humankind, etc..)
The sample that I the test came from the poultry, the pig, and humankind.

From 100 samples, there is 20 that succeeded in being turned on and evidently 11 among them had spesifisitas the receptor 2,6.

Meaning that, these viruses had the capacity immediately could infect humankind without must from the poultry before.

Moreover, some of the samples had the amino acid lisin in the number 627 proteins PB2, that meaning that the virus could be stable in the temperature of the human body.

The above translation of an interview with CA Nidom from the Airlangga University Vetereinary School in Surabaya is cause for concern.  The comments indicate that 20% of the samples tested had virus (presumably H5N1) and 55% of the positives had a 2,6 receptor specificity, indicating they had an increased affinity for human receptors in the upper respiratory tract.  In addition, many had PB2 E627K, which allows the H5N1 to grow at lower temperatures.

Earlier reports described E627K in one of the initial samples from Jakarta, A/Indonesia/6/2005(H5N1).  There was additional speculation that the high levels of H5N1 bird flu in the nose and throat of victims in Medan were also due to E627K.

The above comments indicates thee are differences in receptor specificities in the H5N1 isolates from Jakarta.  The comments above to not break down the number of H5N1's with 2.6 specificities, but H5N1 can readily recombine and exchange such information, so finding that specificity in H5N1 in any of the tested species is cause for concern.

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