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Paradigm Shift Intervention Monitoring
Swine H3N2v Human Matches
The latest sequences contained the earliest (August 22. 2011) matches (A/swine/Iowa/A01202529/2011 and A/swine/Iowa/A01202530/2011) with the human H3N2v cases, which are after the first human case in July, but in the same time frame as the three Pennsylvania cases in August, 2011.
The H3 from the two isolates were identical with each other and a September 9, 2011 collection from Iowa, A/swine/Iowa/A01202878/2011, as well as previously described sequences from Illinois (A/swine/Illinois/A00857300/2011, A/swine/Illinois/A00857138a/2011, A/swine/Illinois/A00857138b/2011. Matches were also seen in the N2 and MP gene segments.
Full sequences from the previously described Illinois isolates, as well as sequences from New York (A/swine/NY/A01104005/2011) and Iowa (A/swine/Iowa/A01202640/2011) match the human H3N2v cases in all 8 gene segments, indicating this sub-clade spread rapidly in swine in the fall of 2011.