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Paradigm Shift Intervention Monitoring
Live feed of underlying pandemic map data here
The recently released HA
sequence from A/swine/Iowa/03032/2010
has a six BP duplication which includes G158E. Thus instead of
the wild type sequence for positions 156-159 changing from KKGN to
KKEN, as found in many low reactors, the Iowa swine sequence has
KKEKEN, which almost certainly leads to significant immunological
The isolate was collected a month ago and the genetic background is similar to humans infected by swine H1N1 in 2007 in Ohio. However, the sequence has also acquired pH1N1 sequences that are found in almost all pH1N1 isolates. Moreover, most of these polymorphisms are non-synonymous and at least one polymorphism traces back to 1918.
These acquisitions raise concerns that this virus could quickly gain efficient and sustained transmission in humans, leading to a co-circulating H1N1 pandemic.
More intense screening of swine in the United States would be useful.