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Paradigm Shift Intervention Monitoring
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26 the CDC notified Recombinomics that the GISAID entry on antiviral
resistance is in ERROR. A/Kansas/05/2010 is SENSITIVE to
oseltamivir and Zanamivir.
A second sequence, A/Connecticut/23/2009, was also released by the CDC today, and it also had I466M, which was also on an earlier sequence from Poland, A/Poland/37/2009. None of the above sequences had H274Y.
Resistance to the two first line neuramindase inhibitors (and it is likely that the M2 sequence also has S31N, conferring resistance to adamantines) in the same sequence is cause for concern.
Information on the resistance in the patients from Connecticut and Poland would be useful.