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Paradigm Shift Intervention Monitoring
Has 2011 H3N2v Genes Including MP
Unlike the H1N2 isolate from 2011, A/Minnesota/19/2011, the current sequence has an H1N1pdm09 M gene that is closely related the M gene in 2011 human cases, which is also true for PB2, PA, NA, and MP, raising concerns of human adaptation. This increased transmission is also supported by the detection of three cases, which is more than the two H1N2v human cases described previously.
In addition the other three genes are from lineages found in prior human isolates. The H1 is the same lineage as the 2011 case, A/Minnesota/19/2011, which was a case with no swine exposure. The PB1 is the same lineage found in the two 2007 cases, A/Ohio/1/2007 and A/Ohio/2/2007, while the NS is the same lineage as the H1N1v from Wisconsin, A/Wisconsin/28/2011.
The above constellation is unique, and detection in three H1N2v cases in Minnesota is cause for concern.