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Tamiflu Resistance Worldwide
September 29, 2008
The newly released WHO
report on oseltamivir resistance in the southern Hemisphere leaves
little doubt that H274Y is being fixed
in Brisbane/59 clade 2B. Although there are some pockets of H1N1
that are not Tamiflu resistant, many countries are reporting frequencies
approaching 100% including South Africa (129/129), Cameroon (2/2), El
Salvador (7/7), United States (2/3), Uruguay (6/7), United Kingdom
(1/1), Australia (25/26), New Caledonia (3/3), New Zealand (1/1),
These latest results strongly suggest that H274Y is quickly becoming
fixed in Brisbane/59, and this version of H1N1 is widespread.
Although the numbers in countries in the northern hemisphere are low,
these numbers should increase markedly as the influenza season
starts in the northern hemisphere. It is likely that
Tamiflu will have little utility for treating H1N1 in areas were
Brisban/59 is dominant. If H1N1 becomes common in
these areas, there will be serious concerns over the utility for the
use of Tamiflu to blunt an H5N1 pandemic, because of the homology
between the N1 in H1N1 and H5N1.
The worldwide fixing of H274Y is an increasing cause for concern.
at Nature Precedings