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Paradigm Shift Intervention Monitoring
H1N1v Case In
Ontario Canada Has H1N1pdm09 M Gene
The HA gene was found to have nucleotide sequence homologies of:
• 98.8 percent to the HA of the H1N1v reported in Missouri earlier this month
The above comments from a recent ProMED update confirm that the hospitalized H1N1v case in southwestern Ontario has the H1N1pdm09 M gene and is closely related to the recent US case, A/Missouri/12/2012. Thus, all variant cases in North America since 2010 have had PB1 E618D (6 H3N2v cases in 2010 and 1 H1N2v cases in 2011) or H1N1pdm09 M gene (12 H3N2v and 1 H1N1v case in 2011 as well as 306 H3N2v, 4H1N2v and 2 H1N1v cases in 2012).
Moreover, media reports suggest that the Ontario case may have had exposures in the United States, suggesting H1N1v is circulating in Minnesota, which is in addition the 4 confirmed H1N2v cases and 4 confirmed and 1 probable H3N2v cases. Thus, all three serotypes appear to be con-circulating in Minnesota, while 2 or more of each sub-types are circulating in North America in 2012.
Both of these situations are without precedent.