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New Indiana and Maine trH3N2 Cases Raise Pandemic Concerns
Recombinomics Commentary 12:45
November 1, 2011

The CDC has released sequences (at GISAID) for new trH3N2 cases in Indiana, A/Indiana/11/2011, and Maine, A/Maine/07/2011.  Full sequences from the Indiana case (59M collected October 22) indicate all 8 gene segments are closely related to the five prior 2011 trH3N2 cases.  Partial sequences (HA, NP, MP) from the Maine case (8M collected October 24) indicate it is also closely related to the prior human isolates from 2011.  The CDC is again commended for the rapid release of these important sequences.

These sequences leave little doubt that the novel trH3N2 human contagion is transmitting in humans.  More detail on swine contacts would be useful.  However, it is clear that trH3N2 in humans is far more common than indicated by the seven trH3N2 cases. 

A recent CDC paper describes fatal unsubtyables in the 2009/2010 season, which may represent additional trH3N2 cases which have not yet been confirmed.

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