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Hospitalized Indiana Veterinarian With trH3N2
Recombinomics Commentary 12:30
November 10, 2011

Event Information Site for IHR National Focal Point,2011/11/2 Source: WHO Event Information Site for IHR National Focal Point, 2011/11/2
U.S. 11 / 1 reported two cases of swine-derived H3N2 influenza cases, prior to the onset had a history of contact with pigs.

1 case of 8-year-old boy, the incidence of 10/22, 10/24 medical treatment; the other 1 case of 58-year-old male veterinarian, the incidence of 10/20, 10/21-10/24 hospital. The United States this year, total 7 cases swine-derived H3N2 influenza cases so far in 2005 total of 15 cases.

The above translation is from a Taiwan CDC warning of travel to the US due to human cases of trH3N2.  It cites information from a password protect WHO site (National Focal point) used to report diseases covered by International Health Regulations (IHR).  The report above provides additional detail on two most recently reported trH3N2 cases.

The case from Indiana (reported as 59M and represented by A/Indiana/10/2011 by the US CDC) is a veterinarian who was hospitalized for three days, raising concerns that the novel constellation of genes seen in all seven human trH3N2 due to 2011 infections has jumped to swine in Indiana.

The current constellation of gene has never been reported in swine, but increase swine surveillance identified 2010 and 2011 trH3N2 isolates from Indiana swine (A/swine/Indiana/A0109091/2010, A/swine/Indiana/A01049744/2011, A/swine/Indiana/A01049745/2011,  A/swine/Indiana/A01049653/2011), which were closely related to the 2010 human isolates, including a swine M gene, as well as a trH1N2 isolate with an N2 and M gene closely related to the human trH3N2, A/swine/Indiana/A01049964/2011, as noted.

More information of testing of swine linked to the veterinarian would be useful.

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