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An H1N1 influenza A virus, A/swine/Ohio/24366/07, was isolated from pigs in an Ohio county fair. Twenty-six people who came in contact with the infected pigs developed respiratory disease and two of these people were laboratory confirmed as H1N1 by the Centers for Disease Control and Prevention (CDC). The A/swine/Ohio/24366/07 virus we isolated from swine was shown at the CDC to have 100% identical genome sequence to the human virus associated with the county fair.
The above comments describe the largest triple reassortant outbreak reported to date, other than the 2009 pandemic. That outbreak involved H1N1, which was isolated from a presenter and her father as well as multiple swine at the 2007 Huron County fair. However, influenza reassorts in swine, so the same internal proteins can be found in H3N2 isolates which have swapped H3 and N2 for H1 and N1.
The recent pager
alert on two trH3N2 cases in the United States (Wisconsin and
Pennsylvania) focused attention on the five reported cases. All
have been reported after the 2009 H1N1 pandemic and have raised
concerns that they may signal an H3N2 swine flu pandemic.
The conservation of these sequences and linkage
to human trH1N1 and trH3N2 cases raise pandemic concerns.