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Paradigm Shift Intervention Monitoring
Live feed of underlying pandemic map data here
The CDC has released full
sequences (at GISAID) from the four most recent trH3N2 cases
(A/Wisconsin/12/2010, A/Pennsylvania/14/2010, A/Minnesota/09/2010,
A/Iowa/16/2009). All four have the same unusual
NP seen in Kansas/13/2009. Similarly, all five have D225G in
HA and four of the five have E618D
The only trH3N2 sequences at GISAID with PB1 E618D are from these four patients (not in Iowa/16). This marker is in virtually all pH1N1 sequences, signaling human adaptation.
The matches between all five sequences signal human to human transmission and the start of a swine H3N2 pandemic.