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CDC Claim of Widespread Novel trH3N2 In Swine Is False
Recombinomics Commentary 18:40
November 25, 2011

Prior to the three cases in Iowa, most human infections with this virus were associated with exposure to swine. In Iowa, however, no swine exposure has been identified. At this time, it appears that unsustained human-to-human transmission may have occurred. These viruses have been reported in swine in several states in the United States.

The above comments from the November 22, “Have You Heard?” acknowledge that novel trH3N2 is transmitting human to human in Iowa, but maintains that this virus is widespread in swine, which is false.

A year ago WHO issued an page alert because two trH3N2 cases had been identified in Illinois (A/Wisconsin/12/2010) and Pennsylvania (A/Pennsylvania/14/2010), which was followed by the release of sequences from those cases, as well as sequences from the prior human cases involving SOIV’s (Swine Origin Influenza Viruses).  All 13 cases between 2005 and 2009 were H1 triple reasortants (12 H1N1 and 1 H1N2) and had similarities with swine isolate with the same serotype.  However, the H3 triple reassortants were first reported in August 2009, and all the sequences from 2010 were beginning to cluster.  After the pager alter, sequences from two more 2010 isolates were released, A/Minnesota/11/2010 and A/Pennsylvania/40/2010, which expanded the clustering of the human isolates, in marked contrast to lack of clustering by the trH1 human cases.

This clustering became much clearer when the 2011 sequences were released.  Five of the gene segments, including H3, matched the clustered 2010 isolates.  PB1 was an earlier version of the sequences in the 2010 isolates, while NA was from the Pennsylvania cases in the pager alert.  Moreover, the M gene was from H1N1pdm09.  This novel constellation, which had evolved from the dominant human sequences from 2010, clear represented a human contagion, where all 8 gene segments matched all 10 human cases in 2011.
This frequency of this novel trH3N2 in 100% of the human cases was remkarkably reduced in swine. In spite of enhanced swine surveillance, the first and only example,
A/swine/NY/A01104005/2011, was just made public this month.  Thus, the claim that “these viruses have been reported in swine in several states” is false.  There have been triple reassortants found in swine, and in fact the triple reassortants have become dominantt and include H1N1, H1N2, and H3N2 is swine, but the novel trH3N2 in all ten of the 2011 human cases has only been found in one swine isolate.

Thus, the CDC continues to distort the data to maintain its “swine exposure” narrative, which usually employs carefully parsed statements that are factually correct, but highly misleading

However, the claim that the 2011 novel trH3N2 has been reported in swine in many states is simply false.

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