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WHO Issues Pandemic H3N2pdm11 CDC PCR Kit Guidance
Recombinomics Commentary 02:45
December 03, 2011

Three cases of human infection with a novel influenza A virus in children were recently reported by the United States of America. The virus is a reassortant between the swine-origin Influenza triple reassortant A(H3N2) viruses circulating in the swine population in the United States of America since 1998 and the A(H1N1)pdm09 virus (M gene only). Sequences of whole genomes of the three viruses have been uploaded in GISAID. A candidate reassortant vaccine virus developed from A/Minnesota/11/2010 is available. The WHO Global Influenza Surveillance and Response System (GISRS) has been informed and guidance to laboratories using CDC real-time RT-PCR diagnostic kits to detect this new reassortant virus has been issued.

The above comments are from the WHO update on influenza activity.  The update notes that the vaccine seed stocks, (sequences released at GISAID August 3) were available and guidance for use of PCR test kit for indirect detection of H3N2pdm11 has been issued.

This kit includes an NP target which cross reacts with H3N2pdm11, as does H3 with seasonal target.

The sequences from A/Iowa/07/2011, A/Iowa/08/2011, A/Iowa/09/2011 are currently available at GISAID and Genbank sequences are being processed and should be accessible shortly (which will activate above links, which have accession numbers).

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