|Home||Founder||What's New||In The News||Consulting|
Paradigm Shift Intervention Monitoring
Live feed of underlying pandemic map data here
D225N in Ukraine
Raises Pandemic Concerns
All sequences are the same sub-clade and collected within a day of each other. They are likely from six fatal cases, once again highlighting the significance of the receptor binding domain and arguing for transmission, since each change is in at least two samples and a change at position 225 is found in 100% of the fatal samples. Both of these changes had been identified in fatal lung infections in Sao Paulo, further linking recent changes (D225G and D225N) to severe and fatal cases.
More detail on the status of these patients and sample source would be useful, as would sequence data from multiple sites in the same patient.
However, it is increasingly clear that the receptor binding domain changes are transmitting and are associated with severe and fatal infections.