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High Attack Rate in
Resistant Cluster in Vietnam
The above description of efficient transmission of H274Y in pandemic H1N1 is from today's New England Journal of Medicine, which confirms the presence of fit virus with H274Y. The attack rate was high. At least seven of ten students were infected, and all had H274Y. Although all recovered, one patient continued to shed virus for 9 days. This cluster was in Vietnam in July and highlights the ease of transmission of H274Y.
Recent clusters of human to human transmission have been described in hospital settings in North Carolina and Wales and in North Carolina, 3 of 4 patients died, raising additional concerns that the H274Y currently transmitting is not only fit, but also lethal.
The high penetration rate in Vietnam suggests H274Y is widespread in mild cases, but is largely undetected because of limited testing. However, media reports in August suggested H274Y was spreading in Vietnam and recent reports suggest 6% of cases in Vietnam may have H274Y.
In the US, the detection of H274Y has recently increased almost 10 fold, signaling a crossing of a tipping point.