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Paradigm Shift Intervention Monitoring
Comments On WV trH3N2 and MN trH1N2 In Swine
The above comments are from the Pan American Health Organization (PAHO) summary of the two recent novel influenza viruses (trH3N2 – A/West Virginia/06/2011 and trH1N2 – A/Minnesota/19/2011) reported in EW 49. As indicated, the two cases had no swine exposure. However, the two isolates were unique reassortants, and the statement that both are known to circulate in swine in the United States, or any swine, is false. Both of these viruses are reassortants of 2010 and 2011 isolates concentrated in humans. The number of known matches is very limited, and the two new variants do not match any reported swine sequence.
The West Virginia isolate is a reassortant that matches the 2011 isolate in 7 of the 8 gene segments. The seven matching gene segments have only been reported in one swine isolate, which is from New York (A/swine/NY/A01104005/2011) and matches the 10 human 2011 cases (H3N2pdm11) in all 8 gene segments. The newly acquired NA gene segment in A/West Virginia/06/2011 creates a new constellation which does not match the New York swine or any reported swine sequences in the United States or anywhere else in the world.
Similarly, the trH1N2 sequence from Minnesota is also a reassortant and also unique. It has acquired an H1 and N2 from the same parental sequence, A/swine/Ohio/FAH10-1/2010, that created H3N2pdm11 from the dominant 2010 sequence in humans (which acquired PB1, NA, MP from the H1N2 parent). The 2010 sequences were clustered in humans and all six 2010 human sequences had a PB1 gene that was linked to the trH1N1 isolates from the Huron County cases from 2007. However, the human cases acquired an H1N1pdm09 polymorphism, E618D. This change was not present in any swine prior to the 2009 pandemic, and the only swine, other than those with a H1N1pdm09 PB1, were related to human isolates which were precursors for the swine sequences. However, the five Pennsylvania swine sequences related to A/Pennsylvania/14/2010, were H3N2, while the Michigan swine sequence related to A/Minnesota/11/2010 was H1N1. Thus, there are no reported H1N2 swine sequences with E618D on the PB1 lineage, which is present in all six 2010 human isolates.
The failure of the CDC, PAHO, and by extension WHO to understand the unique nature of these recent isolates raises serious pandemic concerns related to the ability of these agencies to understand the emerging trH3N2 that is spreading in a sustained manner in humans.
CDC continues to try to force the sequence data into its “swine exposure” narrative which has no scientific or factual basis. They have yet to link any of the 2011 human isolates to any swine, and the only epidemiological linkage is to human contacts in Iowa.
The failure of the CDC and WHO to understand the evolution and relationship of the novel human sequences with each other, as well as distinctions in swine isolates, again increases serious pandemic concerns.