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Iran December H1N1 Sequences Match United Kingdom
Recombinomics Commentary 20:45
December 26, 2010

The National Influenza Centre in Tehran has released three sets of recent H1N1 sequences which are closely related to recent sequences from the United Kingdom.  One of the HA sequences, from A/Karaj/5327/2010, has S188T (see list here) as well as T1056C and G1403A (here and here) which were present in A/England/4880374/2010, which also had E375K (see list here).  The other two HA sequences, from A/Shahriar/5336/2010 and A/Bandar Abbas/5096/2010, are related to A/England/118/2010 (see lists here and here).

All three of the sequences from Iran were from samples collected in December, 2010, confirming that the sequences in the UK are spreading throughout the northern hemisphere.

The Iran sequence with S188T has two additional non-synonymous changes, S146G and A200T (see lists here and here) which were also in A/BRUNEI/218/2010, further confirming the rapid evolution and spread of the S188T sub-clade. 

These new acquisitions provide additional support for rapid evolution via recombination and raise concerns that the emerging H1N1 is quickly evolving the 2009 sequences.

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