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Paradigm Shift Intervention Monitoring
The National Influenza Centre in
Tehran has released three sets of recent H1N1 sequences which are
closely related to recent sequences from the United Kingdom. One
of the HA sequences, from A/Karaj/5327/2010, has S188T (see list here)
as well as T1056C and G1403A (here
which were present in A/England/4880374/2010, which also had E375K (see
The other two HA sequences, from A/Shahriar/5336/2010 and A/Bandar
Abbas/5096/2010, are related to A/England/118/2010 (see lists here
All three of the sequences from Iran were from samples collected in December, 2010, confirming that the sequences in the UK are spreading throughout the northern hemisphere.
The Iran sequence with S188T has two additional non-synonymous changes, S146G and A200T (see lists here and here) which were also in A/BRUNEI/218/2010, further confirming the rapid evolution and spread of the S188T sub-clade.
These new acquisitions provide additional support for rapid evolution via recombination and raise concerns that the emerging H1N1 is quickly evolving the 2009 sequences.