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![]() ![]() Commentary Spread of H1N1 Tamiflu Resistance In Sapporo
Japan Similar clonal expansion of sequences containing H274Y was seen in southern United States (Louisiana and Mississippi), but those sequences (A/Louisiana/07/2013, A/Louisiana/08/2013, A/Louisiana/10/2013, A/Louisiana/13/2013, A/Mississippi/11/2013) were distinct from the sequences in Sapporo, which are related to sequences in Hong Kong (A/Hong Kong/5008/2013) and the United States (A/Utah/09/2013). In contrast the H274Y sequences in Louisiana and Mississippi are related to sequences that have been widely detected in the US. The onward transmission of H274Y in two sub-clade which are easily distinguished from each other, but related to sequences identified over a wide geographical area, raise concerns that H274Y will continue to spread, which was seen in seasonal H1N1 in the 2008-2009 season. More sequences from Japan and the United States would be useful. Recombinomics
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