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Paradigm Shift Intervention Monitoring
H3N2 T128A Frequency Increases To 40%
The presence of T128A in 6 of the 15 most recent H3 sequences raises concerns that this change is leading to limited efficacy for the H3N2 vaccine and the rapid spread of H3N2 in the US and other countries in the northern hemisphere. The presence of this change is also being reported by other agencies. The first US H3N2 sequences of the current season released by the Navy surveillance system for Department of Defense personnel, A/Oklahoma/3059/2012, has T128A as do the first two sequences released by the Health Protection Agency in the UK.
The CDC reported two more pediatric deaths in the week 52 FluView, increasing the number of deaths reported in the past two weeks to 10, which brings the season total to 18. Media reports have described 5 additional pediatric deaths, raising concerns that the number of cases reported by the CDC will continue to rise. Similarly, the Pneumonia & Influenza death arte increased to 7.0 in the week 52 report, just shy of the epidemic threshold of 7.1%.
Although the CDC is testing a new vaccine target with L157S, A/Hawaii/22/2012, the most recent CDC suggests the loss of the glycosylation site due to T128A, is gaining significant traction.
Recent sequences with T128A
A/Washington/53/2012 83M November 27
A/Florida/46/2012 66F November 23
A/Alabama/24/2012 91M November 19
A/Nevada/27/2012 16M November 18
A/Montana/13/2012 26F November 17
A/Minnesota/17/2012 75F November 14