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Paradigm Shift Intervention Monitoring
Weybridge has released sequences
from all 8 gene segments from a novel H1N2, A/swine/England/1382/2010,
which has internal genes from pandemic H1N1 and an H1 from human H1N1
circulating in the late 70's, early 80's (see list here)
and N2 from human H3N2 circulating in the early 1970’s (see list here).
Thus, the new reassortant has swapped out six swine genes for the six
pH1N1 internal genes (human PB1, avian PB2 and PA, and swine origin NP,
MP, NS), which are linked to human H and N external genes.
This combination is similar to the reassortants in Argentina, which had human H1 and N1 or H1 and N2 with six internal gens from pH1N1. This new constellation is consistent with recent H1N2 isolates from South Dakota which have human H1 and N2, with MP from pH1N1 (sequences from the other 5 genes were not released).
Similarly, sequences from North Carolina were just released which had human H1 and N2 and the polymerase complex from North American triple reassortants, which swapped out the remaining three swine genes for the three genes from pandemic H1N1.
Thus, all of these reassortants have human H and N genes with internal genes that have been found in human hosts, raising concerns that these new reassortants can also jump from swine to human and introduce human H and N genes from the 1970’s, 80’s, and 90’s that have been evolving in swine for 3-4 decades.