Recombinomics | Elegant Evolution

Home Founder What's New In The News Consulting

H1N1 Consulting

Paradigm Shift

Viral Evolution

Intervention Monitoring

Vaccine Screening

Vaccine Development

Expression Profiling

Drug Discovery

Custom Therapies


Audio:Feb16 Mar15 Apr19 May17 RSS Feed twitter News Now                         


Widespread H1N1pdm09 Tamiflu Resistance in Mexico
Recombinomics Commentary 14:15
May 23, 2012

Biologia Molecular y Validacion de Tecnicas in Santo Tomas, Mexico has released a series of 2012 H1N1pdm09 HA and NA sequences at Genbank. Earlier sequences from January collections in Mexico City had H274Y and matched sequences in Texas, California, and Illinois. The latest sequences are more recent and cover a larger geographic area and also have H274Y, extending the spread on H274Y in North America.

All eight of the NA sequences from Mexico had H274Y. They were collected between Jan 2, 2012 (Puebla, A/Mexico/InDRE327/2012, and Feb 28, 2012 (San Luis Potosi City, A/Mexico/InDRE6023/2012). Locations are throughout Mexico (Hidalgo City, A/Mexico/InDRE5498/2012 and A/Mexico/InDRE1818/2012; Tlaxcala City, A/Mexico/InDRE3354/2012; Veracruz City, A/Mexico/InDRE5726/2012; Guanajuato City, A/Mexico/InDRE2440/2012; and Mexico City, A/Mexico/InDRE2718/2012) and match earlier sequences from Mexico City, as well as US sequences in Texas, California, and Illinois.

Although weekly PAHO reports describe the high levels of H1N1pdm09 in Mexico when these samples were collected, the high levels of H274Y were not described.  Recent PAHO and CDC reports have noted increased levels of H274Y in Texas, including 13/16 cases with no Tamiflu exposure. The sequence identities and clonal expansion have not been described.

The familial clusters in the US further confirm the transmission of this sub-clade and the number of cases undoubtedly is many or orders of magnitude higher than the cases represented by the recently released sequences.

Media Link

Recombinomics Presentations

Recombinomics Publications

Recombinomics Paper at Nature Precedings

Home | Founder | What's New | In The News | Contact Us

© 2012 Recombinomics.  All rights reserved.