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H3N2v Confirmed In 4 Attendees of Indiana Grant County Fair
Recombinomics Commentary 02:30
June 27, 2013

State health officials are encouraging Hoosiers to take steps to protect themselves at county and 4H fairs around the state this summer following detection of four cases of variant influenza A (H3N2v). All individuals visited the Grant County Agricultural Fair, June 16-22, prior to illness, and at least two had contact with swine
The above comments from the Indiana State Department of Health (ISDH) press release describe 4 confirmed cases of H3N2v in attendees of the Grant County Agricultural Fair in Marion, Indiana.  H3N2v was also detected in 13 swine at the fair (see map here). 

Recently the USDA released 2013 H3N2v sequences from Indiana swine with collection dates as recent as April 30.  Sequences (H3, N2, MP) from six isolates (A/swine/Indiana/A01260252/2013, A/swine/Indiana/A01260254/2013, A/swine/Indiana/A01260261/2013, A/swine/Indiana/A01260276/2013, A/swine/Indiana/A01260280/2013, A/swine/Indiana/A01260284/2013) were closely related to sequences from 2012 cases, which had an N2 that was closely related to sequences (
A/West Virginia/06/2011) from a West Virginia day care center in late 2011. 

That sub-clade accounted for the vast majority of human cases in 2012 (see BLASTS here).

The detection of four cases, including two without reported contact with swine, raise concerns that the number of 2013 H3N2v cases will exceed 2012.  The first fair related cases in 2012 were in LaPorte, Indiana, which were reported in late July.

Release of 2013 human sequences would be useful.

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