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H3N2v Cluster At Indiana County Fair
Recombinomics Commentary 22:30
July 26, 2012

On July 16, specimens were collected from four persons with respiratory illness; two had become ill on July 12 and sought care at an emergency department, and two were identified as part of the subsequent public health investigation. All four persons were swine exhibitors or family members of swine exhibitors and had close contact with swine.

On July 21, partial genome sequencing at CDC confirmed H3N2v virus with the H1N1pdm09 virus M gene; the viruses detected in the four specimens are similar to 12 viruses detected in 2011 and one detected earlier this year

The above comments from tomorrow’s MMWR describe the largest cluster of confirmed H3N2v cited to date.  Moreover, the detection of H3N2v in contact swine also represents the first reported linkage for H3N2v between an human H3N2v cluster and contact swine.

Recently released sequences by Iowa State University included for June isolates from Ohio (A/swine/Ohio/1/2012, A/swine/Ohio/6/2012, A/swine/Ohio/7/2012, A/swine/Ohio/9/2012) as well as May isolates from Iowa (A/swine/Iowa/A01203503/2012) and Indiana (A/swine/Indiana/A01203521/2012 and A/swine/Indiana/A01203522/2012), which matched the initial human cases from 2011).

However, an additional May isolate from Indiana (A/swine/Indiana/A01203509/2012) match the more recent human cases from West Virginia (A/West Virginia/06/2011 and A/West Virginia/07/2011) and Utah (A/Utah/10/2012), which had an N2 from a swine H3N2 lineage (while the earlier cases had an N2 from a H1N2 lineage).

Thus, it is unclear if the recent cases have the H1N2 or H3N2 N2 gene.  Similarly, it is unclear if the county fair was in Cass or LaPorte, both of which were held from July 8-14.

Release of the human and associated swine sequences would be useful.

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