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Paradigm Shift Intervention Monitoring
More H1N1 Low Reactors In Japan Raises Vaccine
This concern was increased by recently released sequences (by the CDC at GISAID), which included a construct of a new H1N1 target using H1 and N1 on a PR8 genetic background, as well as three new H3N2 targets and three new influenza B targets, indicating the CDC now has major reservations of use of 2009 targets. The new constructs largely use 2010 isolates, like A/South Carolina/02/2010 for the H1N1 target.. The H1N1 target also has K157E and Q226R acknowledging a need for changes in these two critical regions. Two way testing of the new H1N1 target was listed as LOW / FAIL indicating the old vaccine poorly recognized the new target, and a vaccine against the new target poorly recognized the old target (Califorenia/7).
The latest data from Japan once again highlights the reliance of the CDC and WHO on the paradigm of random mutations to be hazardous to the world’s health. The recommendations to WHO and the FDA in the United States was largely based on the assumption that the frequent detection of changes at positions 156-159 was due to lab selection of random mutations, as well as similar changes at positions 225 (D225G and D225N) and 226 (Q226R). the testing of new H1N1 targets with changes at positions 157 and 226 acknowledges that the “lab errors” due to “spontaneous mutations” was false. However in the southern portion of the United States the new school year begins this week and more school seasons will begin later this month in areas to the north.
Last season pneumonia and influenza death rates were at record levels, and the recent results from Japan raises concerns that changes at positions 156-159 will lead to immunological escape, and changes at positions 225 and 226 will target the lungs, leading to more severe H1N1 cases.