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H1N1 M Gene Critical In Human Transmission - trH3N2 Concerns
Recombinomics Commentary 19:30
September 3, 2011

the M segment is a critical factor supporting the transmission of the 2009 pandemic virus

The above comment is from an upcoming paper, “The M segment of the 2009 new pandemic H1N1 influenza virus is critical for its high transmission efficiency in the guinea pig model”.  This finding raises serious concerns about the recently reported trH3N2 cases in Pennsylvania and Indiana, which have acquired the M segment from pandemic H1N1.

This acquisition would lead to more efficient transmission of trH3N2 which acquired the M segment from pandemic H1N1.  The isolate from the patient in Indiana, A/Indiana/08/2011, has genes that are closely related to the genes of early human cases with trH3N2, but it has also acquired the H1N1 MP gene segment. 

This acquisition was also found in the recent Pennsylvania case, raising concerns that the trH3N2 from these two cases is efficiently transmitting in humans.

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