Recombinomics | Elegant Evolution

Home Founder What's New In The News Consulting

H1N1 Consulting

Paradigm Shift

Viral Evolution

Intervention Monitoring

Vaccine Screening

Vaccine Development

Expression Profiling

Drug Discovery

Custom Therapies


Audio:Aug7 Aug8 Aug16 Aug31RSS Feed twitter News Now                         


Kentucky H3N2v Matches Clark County Ohio
Recombinomics Commentary 13:00
September 3, 2012

The recently released CDC H3N2v sequences included those from an August 5 isolate from Kentucky, A/Kentucky/11/2012.  Although all of the July / August H3N2v (41 sets of sequences from Hawaii, Indiana, Ohio, Illinois, Kentucky, Maryland, Michigan, Minnesota, Pennsylvania, West Virginia, Wisconsin) are closely related to each and represent human to human clonal expansion of sequences first reported for the 2011 outbreak at the day care center in Mineral County, West Virginia (A/West Virginia/06/2011 and A/West Virginia/07/2011) and the first 2012 isolate, A/Utah/10/2012, the sequences cluster into sub-clades within the larger sub-clade.  The 2011 West Virginia cluster included 23 ILI cases in the index case contacts, which also had no swine contact or exposure.

The H3 sequence from Kentucky clusters with the Ohio sequences from Clark County, A/Ohio/23/2012, as well as two early isolates from Indiana (A/Indiana/59/2012 and A/Indiana/60/2012).  This clustering provides further support for the human expansion. 

Neither Kentucky nor the CDC has acknowledged H3N2v cases in Kentucky.  Kentucky denies H3N2v in its August 16 press release and health alert, which describe the detection of seasonal H3N2 in children in Ashland, Kentucky, which is in Boyd County.  These cases were initially tested by local practitioners because of the massive outbreak at the Gallia Junior County fair in southeastern Ohio.  In addition to the 200 cases in Ohio, the three H3N2v cases in Mason County, West Virginia were from cases who also attended Gallia fair, and sequences from one of these cases, A/West Virginia/15/2012, were also released by the CDC, and these sequences matched the first case from Jackson County, Indiana, A/Indiana/12/2012 or A/Indiana/13/2012 (as well as additional sequences from Indiana), which were distinct from the Kentucky sub-clade, suggesting the Kentucky case was not linked to Gallia fair.

The Kentucky sequence raises concerns that many of the 188 seasonal H3N2 cases in weeks 31-33 reported in the week 34 FluView represent multiple H3N2v isolates with no swine contact, representing widespread community transmission.

Kentucky and the CDC have failed to respond to repeated inquiries regarding the sequence confirmation of the “seasonal” H3N2 cases reported on August 16.

Answers to that question, as well as detail on the case linked to the Kentucky/11/2012 sequence, would be useful.

Media Link

Recombinomics Presentations

Recombinomics Publications

Recombinomics Paper at Nature Precedings

Home | Founder | What's New | In The News | Contact Us

© 2012 Recombinomics.  All rights reserved.