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Paradigm Shift Intervention Monitoring
Matches With LaPorte and Butler Cases
Thus, the sequence data strongly supports interspecies transmissions at both county fairs.
However, these sequences don’t address the direction of the transmission. Prior to the fairs, only 2 of 31 swine matches with human 2011 and 2012 cases are from the sub-clade found in all 2012 human H3N2v cases. Moreover, none of the 57 public sequences from July and August 2012 cases are from the sub-clade found in the first 10 human cases in 2011. This novel sub-clade was first detected at the West Virginia day care center in late 2011 (A/West Virginia/06/2011 and A/West Virginia/07/2011), as well as the first 2012 H3N2 case, A/Utah/10/2012.
These distribution raise concerns that this novel sub-clade is widespread in humans (July / August cases were identified across the United States, from Hawaii to Maryland) and agricultural fairs create interactions leading to frequent human to swine transmission.