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|Paradigm Shift Intervention Monitoring||Audio: Jan28 Apr21 Sep22
Tamiflu Resistant H1N1 Sub-clade in Europe
More recently, isolates in South Africa and Kenya, had a series of changes in this subclade located near the receptor binding domain at position 190 (H3 numbering), raising concerns that the current vaccine, which targets Brisbane/59 may not be as effective this season.
The sub-clade which dominated last season in the northern hemisphere is evolving, and the evolved versions are associated with an increase in H274Y frequency to 100% in South Africa (225/225 sequenced isolates had H274Y).
The dominance of this sub-clade appears to be extending to the current flu season in the northern hemisphere, where the first H1N1 isolates in Canada and the UK have H274Y.
Dominant H274Y Clade 2B sub-clade
Other H274Y Clade 2B sub-clade