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Paradigm Shift Intervention Monitoring
Denies Novel trH3N2 Circulation In Humans
virus to humans. Should any changes occur, then enhanced surveillance methods will be implemented and incorporated into this report.
The above comments are from the Indiana State Department of Health week 43 report which confirmed the second trH3N2 case in Indiana. The state labs obtained an “inconclusive” in their sub-typing test, and trH3N2 was confirmed by the CDC through sequencing on October 28. The sequences were made public by the CDC on October 31 (at GISAID) which clearly demonstrated that the constellation of genes (from 59M – A/Indiana/11/2011 collected on October 22) matched the six prior cases, including an M gene segment from H1N1pdm09.
Multiple phone calls to the ISDH Surveillance and Investigation Division for clarification were not returned at the time of this commentary. The above statement extends the long list of odd actions and statements by the CDC and recent state reports from Maine and Indiana.
trH3N2 is clearly a “novel” influenza and is a notifiable disease as defined under International Health Regulations. It is one of the categories listed on the weekly notifiable disease page on the CDC’s MMWR, which has cited 7 prior trH3N2 reported in 2011 of which 5 were due to infections in 2011. All five of the 2011 isolates, which include one from Indiana, A/Indiana/08/2011, which was the first reported, match the more recent Indiana isolate, A/Indiana/11/2011, in all eight gene segments, confirming that this novel trH3N2 is circulating in humans. It is in seven of seven human cases, and has not been reported in swine in Indiana, Pennsylvania, Maine, or any other state or country in the world.
Moreover, the first reported 2011 trH3N2 case (2M) was in Indiana and he had no swine contact. The CDC has acknowledged that this case represented human to human transmission. The CDC speculated that the source was his caretaker who had swine contact, but the caretaker and associated swine were asymptomatic and no SOIV infections have been reported.
This lack of a swine exposure was also ignored by the Maine CDC, who claimed that all prior 2011 trH3N2 cases had a swine exposure.
Thus, both of these organizations are trying to support the CDC narrative of no sustained human transmission, by claiming that all cases had a swine exposure and there is no circulation of this virus in humans, even though all isolates reported to date have been in humans, including two cases in Indiana.
The CDC has left trH3N2 unsubtypables out of its subtyping table and figures, and the two cases that were listed as “unable to subtype” in week 35 and 36 reports, removed in week 37 and 38 reports, added back in the week 39 report, and removed from the week 40 report which summarized the cases between weeks 21 and 39, when included all four 2011 trH3N2 cases were confirmed and reported.
The above statement is yet another example of bizarre comments and actions by the CDC and state labs in denial over the human transmission of trH3N2 with an M gene segment from H1N1pdm09, which represent a shell game on unsubtypables and a charade on swine exposure.