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100% H1N1 Tamiflu Resistance in Scotland
Recombinomics Commentary 15:45
November 21, 2008

Two oseltamivir resistant influenza A(H1N1) cases have also been detected in Scotland.

The above comments from today's review of H1N1 oseltamivir resistance in the UK suggest oseltamivir resistance in Scotland is running at 100%.  The weekly Scotland reports for this season descibe two infleunza A isolates, which appear to both be H1N1 based on the above comment.

The report from England also provides more detail on the 12 cases in England, which appear to be largely from young adults.  Thus, to date there appears to be only one H1N1 isolate in northwestern Europe that did not have H274Y.  The totals to date are 12/13 in UK, 2/2 in Scotland, and 1/1 in Norway (although the one case in Norway may have been infected in the United States).

These high frequencies in three countries support H274Y levels at or near 100% in Bisbane/59 isolates in northern Europe, and the 1/1 case in Canada suggest similar Tamiflu resistance levels with be reported in North America this season.

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