Recombinomics | Elegant Evolution

Home Founder What's New In The News Consulting

H1N1 Consulting

Paradigm Shift

Viral Evolution

Intervention Monitoring

Vaccine Screening

Vaccine Development

Expression Profiling

Drug Discovery

Custom Therapies


Audio:Oct 17 Nov 13 Nov21 MAP RSS Feed twitter News Now                         


H1N1pdm09 Louisiana Tamiflu Resistance Cluster Grows
Recombinomics Commentary 20:30
December 3, 2013

Recently released H1N1pdm09 sequences by the CDC identified two cases (25F and 56F) in Louisiana with the oseltamivir resistance marker, H274Y (A/Louisiana/07/2013 and A/Louisiana/08/2013).  The detection of two cases in the same state at the same time (collected Oct 7 & 9) raised concerns since the two cases matched the total number of cases for the 2012/2013 season (A/Pennsylvania/01/2013 (collected Jan 18 and A/Tennessee/03/2013 collected Mar 26). 

The CDC release sequences for all eight gene segments, which showed that the two isolates were virtually identical.  The Louisiana Department of Health indicated the CDC requested additional samples, which led to the identification of a third case (the first 2 cases were cited in week 44 FluView and the third case was in week 45) and all three cases were unlinked.

The CDC recently released sequences for all eight gene segments of the third case 25F, A/Louisiana/10/2013 from a sample collected on October 21.  That set of sequences matched the first two, extending the clonal expansion.  The CDC also released two sets of sequences (A/Louisiana/11/2013 and A/Louisiana/12/2013) which were oseltamivir sensitive, but these sequences were also closely related to the three resistant sequences.

This similarity raises concerns that the sensitive cases are mixtures, with H274Y present in lower concentration.  The possibility of a mixture in the Louisiana sequences is support by newly released sequences from a resistant case (14F) in Utah, A/Utah/10/2013, which has almost equal levels of H274Y and wild type, but is also closely related to the Louisiana sequences.

Media Link

Recombinomics Presentations

Recombinomics Publications

Recombinomics Paper at Nature Precedings

Home | Founder | What's New | In The News | Contact Us

© 2013 Recombinomics.  All rights reserved.