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2010 trH3N2 Recombinant Sequence In Argentina
Recombinomics Commentary 17:35
December 9, 2010

Mill Hill has released a series of H3N2 sequences from Argentina and Cameroon (at GISAID).  The sequences from Argentina had a series of newly acquired polymorphisms representing a new sub-clade initially seen in A/Pennsylvania/02/2010 and A/Kansas/06/2010.  This sub-clade has quickly spread worldwide (see list here here here).

However, one of the Argentina isolates, A/Argentina/27891/2010, has a region in HA that dramatically diverges from this H3N2 background, signaling recombination.  Two consecutive polymorphisms (G1089A and T1092C) are present in recently released trH3N2 sequences, A/Minnesota/09/2010 and A/Wisconsin/12/2010, as well as swine sequences from Iowa and Guangdong and earlier seasonal H3N2 (seelist here here). 

An adjacent polymorphism, G1087A, is also in the swine sequences as well as two Cameroon sequences, A/Cameroon/LEID/03/10/218/2010 and A/Cameroon/LEID/03/10/227/2010, see list here.

These 2010 recombinant sequences signal rapid evolution in the newly emerging H3N2 sequences and may be related to media reports of novel H3N2 sequences in Mongolia and Russia.

Release of the sequences from Mongolia and Russia, as well as Garden Hill, Manitoba, in Canada, would be useful.

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