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2010 trH3N2 Recombinant Sequence In Cameroon
Recombinomics Commentary 23:25
December 9, 2010

Mill Hill released a series of 2010 sequences from Argentina and Cameroon. Most of the Argentina sequences were closely related to a newly emerging sub-clade, which was first seen in Pennsylvania and Kansas.  However, one of the sequences, A/Argentina/27891/2010, had a region of divergence which had three consecutive polymorphisms (G1087A, G1089A, T1092C) that match earlier human H3N2 sequences as well as H3N2 sequences in swine and birds (see list here).  Two of the polymorphisms, G1089A and T1092C were also in two of the recent trH3N2 sequences found in the United States (A/Minnesota/09/2010 and A/Wisconsin/12/2010), while T1092C was also in two additional trH3N2 sequences, A/Iowa/16/2009 and A/Pennsylvania/14/2010, (see lists here here).

In addition to the full HA sequences, Mill Hill also released two partial sequences, and one covered the region described above.  That sequence, A/Cameroon/LEID/03/10/227/2010, also had all three polymorphisms.  Although the Cameroon sequence was also H3N2, it was not the same sub-clade as the sequences from Argentina, placing this series of polymorphisms on yet another H3N2 background, further supporting acquisition by recombination.

Thus, the tandem changes, G1089A and T1092C are present on three different 2010 H3N2 genetic backgrounds,
including trH3N2, in isolates from humans on three different continents (North America, South America, and Africa) .

Theses data increase concerns that trH3N2 is much more widespread in human populations than the five isolates that have been reported from the United States, which highlights the need for more active surveillance and release of sequence data from Canada, Mongolia, and Russia which have reported unusual findings associated with H3N2 infections.

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