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H1N1 Tamiflu Resistance at 100% in Canada
Recombinomics Commentary 01:07
December 20, 2008

however all of the A/H1N1 isolates were resistant to oseltamivir due to the H274Y mutation (resistance = 100% or 3/3). The resistant isolates were from NS and BC.

The above comments from the week 50 influenza report from Canada indicate H1N1 oseltamivir resistance in Canada is currently at 100%.  Although only three isolates have been tested, it is a marked improvement over the one tested at the beginning of the season. The isolates are from the opposite ends of Canada, and match the results in the United States, where 49/50 H1N1 isolates have H274Y.

The United States has issued an advisory to physicians, describing the high levels of resistance in seasonal flu, since the vast majority of flu in the US currently is influenza A and the vast majority of influenza A is H1N1.

The resistance levels in H1N1 in Europe are also near 100% in England, at at 100% in Scotland, Norway, and Austria, although the number of samples tested remain low. However, in Europe most of the influenza A is H3N2, which is sensitive, so an advisory in Europe has not been issued to physicians, although England did put out a report on the high frequency in H1N1.

The levels of resistance in North America and Europe suggest that the resistance levels in H1N1 are not likely to change this season.

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