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Ukraine Fatalities Jump to 940 - Over 4 Million Infected
Recombinomics Commentary 13:20
January 12, 2010

4,106,091 Influenza/ARI

242,246 Hospitalized

940 Dead

The above tally is the latest from the Ukraine Ministry of Health website.  The number dead has increased by 22 in the past 24 h and 42 in the past 48 h, which is close to one death per hour, even though the number of cases per day has decline so only 5 of the 27 regions remain above the epidemic threshold.  In the past 2 days there were 7 deaths recorded for Kyiv and 6 for Donetsk, which now has 134 deaths (see map). 

The high rate of fatalities is of concern because of the high frequency of fatal cases with receptor binding domain changes.  Although several countries have a case fatality rate for H1N1 patients with D225G/N, in Ukraine all 8 sequences from fatal cases have D225G, D225N, or both.

Moreover, similar changes are being reported for adjacent regions in Russia and Moldova, and spikes in fatalities are also being reported in countries in the region, including a cluster in Romainia

Ukraine is being careful watched because of concerns that the sub-clade with these receptor binding domain changes will became more common, leading to a higher rate of severe and fatal cases.  Recent sequences from the Kyiv area had both D225G and D225N, which corresponds to the spread of fatal H1N1 cases.

Sequences from fatal cases in eastern Ukraine would be useful.

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