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Paradigm Shift Intervention Monitoring
St Jude released a series of
sequences from swine isolates from 2009 and 2010 which were triple
reassortants which had acquired pandemic H1N1 gene segments. One of the
examples was an trH3N2 isolate, A/swine/Minnesota/239105/2009,
which had acquired pandemic H1N1 sequences, which replaced PA, NP, and
Other sequences from H1N1 and H1N2 isolates from swine in Minnesota also had pandemic H1N1 genes, which are also true for H1N2 swine isolates from Argentina, England, South Korea, and multiple locations in the United States including South Dakota, North Carolina (including 2 distincy constellations), and Indiana.
These recent sequences highlight the ability of pandemic H1N1 virus to exchange genes with other triple reassortants (trH3N2, trH1N1, trH1N2), which are widespread in swine worldwide. The swapping is likely facilitated by the fact the pandemic H1N1 is also a triple reassortant and the polymerase complexes are composed of one human (PB1), and two avian (PB2 and PA) flu gene segments. However, these gene segments have significant sequences, especially those that have been evolving in swine for decades. Many of the triple reassortants also have human flu derived H and N genes, raising concerns that these new combinations will move these novel viruses into the human population.