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H3N2v In Symptomatic Swine At LaPorte County Fair
Recombinomics Commentary 00:45
July 27, 2012

Following reports of ill swine and humans during a fair in Indiana from July 8-14, samples were taken from swine and humans. Twelve swine were randomly sampled by Indiana state animal health officials, tested at Indiana and Federal animal diagnostic laboratories, and found to be infected with swine influenza A (H3N2) viruses. Four people tested positive for influenza A (H3N2) variant virus.* Genetic testing confirmed that the viruses found in humans and those found in swine in this situation are nearly identical and both have the M gene from the pandemic H1N1 virus.
The above comments are from the CDC “Have You Heard” and confirm that the H3N2v positive swine were symptomatic and the sequences were closely related to the four human confirmed cases from the La Porte County fair, as well as prior human cases in 2011 and 2012, which also had an H1N1pdm09 M gene.
The detection of H3n2v in humans and swine contacts is in marked contrast to the prior 13 H3N2v cases in 2011 and 2012.  Six of those cases had no swine contact, while the seven with contact had contact with asymptomatic swine, or symptomatic wine which tested negative for influenza.

This linkage between human cases and swine is of concern because recently released swine sequences by Iowa State University depict and increasing frequency of H3N2v swine matches with the human cases, which includes four matches in May (in Iowa and Indiana) as well as 4 matches in June (in Ohio), in addition to the 12 July matches described above at the LaPorte county fair.

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