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Identical H3N2v Sequences In LaPorte County Fair Cases
Recombinomics Commentary 02:30
July 28, 2012

The CDC has released three sets of sequences from the LaPorte County Fair in Indiana.  The first series was from direct sequencing of the clinical sample from one patient, designated A/Indiana/07/2012.  That series was followed by two cloned isolates, one from A/Indiana/07/2012 and the other from a second case, A/Indiana/09/2012.

The initial direct sequence was closely related to sequences from West Virginia (A/West Virginia/06/2011 and A/West Virginia/07/2011) and Utah (A/Utah/10/2012), as noted.

The cloned sequences represented full sequences for all 8 gene segments, and the two sets of sequences were identical, confirming a common source.  In addition to an N2 sequence related to N2 circulating in swine H3N2, the LaPorte cluster sequences were closely related to the recent cases cited above, signaling the emergence of a novel constellation in human cases. 

This constellation and lineage was also present in sequences (H3, N2, MP) from two swine isolates (A/swine/North Carolina/A01203272/2012 and A/swine/Indiana/A01203509/2012) and presumably the 12 isolate from swine at the LaPorte County Fair.

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