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Paradigm Shift Intervention Monitoring
Sequences In LaPorte County
The initial direct sequence was closely related to sequences from West Virginia (A/West Virginia/06/2011 and A/West Virginia/07/2011) and Utah (A/Utah/10/2012), as noted.
The cloned sequences represented full sequences for all 8 gene segments, and the two sets of sequences were identical, confirming a common source. In addition to an N2 sequence related to N2 circulating in swine H3N2, the LaPorte cluster sequences were closely related to the recent cases cited above, signaling the emergence of a novel constellation in human cases.
This constellation and lineage was also present in sequences (H3, N2, MP) from two swine isolates (A/swine/North Carolina/A01203272/2012 and A/swine/Indiana/A01203509/2012) and presumably the 12 isolate from swine at the LaPorte County Fair.